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Yes. Avianca and LATAM fly nonstop from Quito (UIO) to Manta (MEC), several times daily. The flight takes about 51m and covers 170 miles (274 km).
Avianca, LATAM operate nonstop flights from Quito to Manta.
The nonstop flight from Quito to Manta takes ~51m (approximately 274 km).
Nonstop flights from Quito to Manta operate several times daily.