Direct flights from St Louis to San Diego

  • 9 flights a week
  • Southwest Airlines

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When the nonstops leave

Typical weekly schedule · 9 flights per week · Updated 89d ago

Most leave in the morning.

Morning before noon 6 a week

Arrive the same day

8:10 AMnot Sat
Afternoon noon – 6 PM 1 a week

Arrive the same day

2:20 PMSat
Evening after 6 PM 2 a week

Arrive the same day

8:50 PMSat 9:35 PMSun
Southwest Airlines Departs Terminal 2 Arrives Terminal 1

More nonstops from St Louis

STL → MCO Orlando 2 airlines STL → SLC Salt Lake City 2 airlines STL → BNA Nashville STL → BWI Baltimore STL → DAL Dallas STL → MCI Kansas City STL → MDW Chicago STL → PIT Pittsburgh SAN → STL The return trip STL All nonstops from St Louis SAN All nonstops from San Diego

Frequently asked questions

Is there a direct flight from St Louis to San Diego?

Yes. Southwest Airlines flies nonstop from St Louis (STL) to San Diego (SAN), daily. The flight takes about 3h 42m and covers 1,554 miles (2,501 km). Schedule data from 22 July 2026.

Which airlines fly direct from St Louis to San Diego?

Southwest Airlines operates nonstop flights from St Louis to San Diego.

How long is the flight from St Louis to San Diego?

The nonstop flight from St Louis to San Diego takes ~3h 42m (approximately 2501 km).

How often do direct flights operate from St Louis to San Diego?

Nonstop flights from St Louis to San Diego operate daily — 9 flights per week.

What days of the week are there direct flights from St Louis to San Diego?

Direct flights from St Louis to San Diego operate every day of the week.