Direct flights from St Louis to Chicago

  • ~5 flights a day
  • Southwest Airlines

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When the nonstops leave

Typical weekly schedule · 36 flights per week (~5 per day) · Updated 84d ago

Morning before noon 17 a week

Arrive the same day

5:40 AM 8:55 AM4 days a week 9:00 AMSun 9:40 AMTue, Wed 10:20 AMFri 11:20 AMTue, Wed
Afternoon noon – 6 PM 13 a week

Arrive the same day

12:40 PMMon, Thu, Fri 1:30 PMSun 2:35 PMFri 3:35 PM4 days a week 4:00 PMSat 4:25 PMSat 5:55 PMTue, Wed
Evening after 6 PM 6 a week
6:30 PMMon, Thu, Fri 8:05 PMFri 8:20 PMThu 9:55 PMThu
Southwest Airlines Departs Terminal 2

More nonstops from St Louis

STL → MCO Orlando 2 airlines STL → SLC Salt Lake City 2 airlines STL → BNA Nashville STL → BWI Baltimore STL → DAL Dallas STL → MCI Kansas City STL → PIT Pittsburgh STL → CLE Cleveland MDW → STL The return trip STL All nonstops from St Louis MDW All nonstops from Chicago

Frequently asked questions

Is there a direct flight from St Louis to Chicago?

Yes. Southwest Airlines flies nonstop from St Louis (STL) to Chicago (MDW), several times daily. The flight takes about 1h 1m and covers 251 miles (404 km). Schedule data from 27 July 2026.

Which airlines fly direct from St Louis to Chicago?

Southwest Airlines operates nonstop flights from St Louis to Chicago.

How long is the flight from St Louis to Chicago?

The nonstop flight from St Louis to Chicago takes ~1h 1m (approximately 404 km).

How often do direct flights operate from St Louis to Chicago?

Nonstop flights from St Louis to Chicago operate several times daily — 36 flights per week (~5 per day).

What days of the week are there direct flights from St Louis to Chicago?

Direct flights from St Louis to Chicago operate every day of the week.