Direct flights from Chicago to St Louis

  • ~6 flights a day
  • Southwest Airlines

🔔 Track this route

We check MDW → STL every day and email you the cheapest nonstop fares we find.

Free · one-click unsubscribe

When the nonstops leave

Typical weekly schedule · 42 flights per week (~6 per day) · Updated 80d ago

Morning before noon 15 a week

Arrive the same day

6:15 AMSat 6:30 AMSat 7:50 AM 11:00 AMnot Sat
Afternoon noon – 6 PM 13 a week

Arrive the same day

1:00 PMnot Sat 2:35 PMSat 2:45 PM5 days a week 4:50 PMSun
Evening after 6 PM 14 a week

Arrive the same day

6:00 PM5 days a week 6:10 PMSat 6:30 PMSun 9:35 PM
Southwest Airlines Arrives Terminal 2

More nonstops from Chicago

MDW → AUS Austin MDW → BNA Nashville MDW → BWI Baltimore MDW → CLE Cleveland MDW → LGA New York MDW → MCI Kansas City MDW → MEM Memphis MDW → OMA Omaha STL → MDW The return trip MDW All nonstops from Chicago STL All nonstops from St Louis

Frequently asked questions

Is there a direct flight from Chicago to St Louis?

Yes. Southwest Airlines flies nonstop from Chicago (MDW) to St Louis (STL), several times daily. The flight takes about 1h 1m and covers 251 miles (404 km). Round-trip fares typically run around $489. Fares last checked 15 October 2026.

Which airlines fly direct from Chicago to St Louis?

Southwest Airlines operates nonstop flights from Chicago to St Louis.

How long is the flight from Chicago to St Louis?

The nonstop flight from Chicago to St Louis takes ~1h 1m (approximately 404 km).

How often do direct flights operate from Chicago to St Louis?

Nonstop flights from Chicago to St Louis operate several times daily — 42 flights per week (~6 per day).

What days of the week are there direct flights from Chicago to St Louis?

Direct flights from Chicago to St Louis operate every day of the week.

How much is a round-trip flight from Chicago to St Louis?

Round-trip flights from Chicago (MDW) to St Louis (STL) start at $449, with a typical fare around $489. Based on 6 recent fare combinations.