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Yes. Avianca, United Airlines and Vuela El Salvador fly nonstop from San Salvador (SAL) to Houston (IAH), several times daily. The flight takes about 3h and covers 1,211 miles (1,949 km).
Avianca, United Airlines, Vuela El Salvador operate nonstop flights from San Salvador to Houston.
The nonstop flight from San Salvador to Houston takes ~3h (approximately 1949 km).
Nonstop flights from San Salvador to Houston operate several times daily.