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Yes. Avianca, United Airlines, Vuela El Salvador and Frontier Airlines fly nonstop from Houston (IAH) to San Salvador (SAL), several times daily. The flight takes about 3h and covers 1,212 miles (1,950 km).
Avianca, United Airlines, Vuela El Salvador, Frontier Airlines operate nonstop flights from Houston to San Salvador.
The nonstop flight from Houston to San Salvador takes ~3h (approximately 1950 km).
Nonstop flights from Houston to San Salvador operate several times daily.