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Yes. TAP Air Portugal flies nonstop from Porto (OPO) to São Paulo (GRU), 3–4 times a week. The flight takes about 10h 59m and covers 5,083 miles (8,180 km).
TAP Air Portugal operates nonstop flights from Porto to São Paulo.
The nonstop flight from Porto to São Paulo takes ~10h 59m (approximately 8180 km).
Nonstop flights from Porto to São Paulo operate 3–4 times a week.