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Yes. Lufthansa and Lufthansa City Airlines fly nonstop from Marseille (MRS) to Frankfurt (FRA), several times daily. The flight takes about 1h 30m and covers 482 miles (775 km).
Lufthansa, Lufthansa City Airlines operate nonstop flights from Marseille to Frankfurt.
The nonstop flight from Marseille to Frankfurt takes ~1h 30m (approximately 775 km).
Nonstop flights from Marseille to Frankfurt operate several times daily.