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Yes. China Southern Airlines flies nonstop from Guiyang (KWE) to Guangzhou (CAN), several times daily. The flight takes about 1h 27m and covers 461 miles (742 km).
China Southern Airlines operates nonstop flights from Guiyang to Guangzhou.
The nonstop flight from Guiyang to Guangzhou takes ~1h 27m (approximately 742 km).
Nonstop flights from Guiyang to Guangzhou operate several times daily.