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Yes. China Southern Airlines flies nonstop from Guangzhou (CAN) to Guiyang (KWE), several times daily. The flight takes about 1h 27m and covers 461 miles (742 km).
China Southern Airlines operates nonstop flights from Guangzhou to Guiyang.
The nonstop flight from Guangzhou to Guiyang takes ~1h 27m (approximately 742 km).
Nonstop flights from Guangzhou to Guiyang operate several times daily.