Direct flights from Des Moines to Chicago DSM → ORD
American Airlines and United Airlines operate nonstop flights from Des Moines (DSM) to Chicago (ORD). The nonstop flight takes around ~0h 36m, covering 298 miles (480 km). Round-trip fares currently start at $247, with a typical fare around $301 across 343 recent fare combinations. Updated 28 June 2026.
60-day flexibility overview based on 343 recent fares across the next 60 days
Cheapest combos
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Frequently asked questions
Is there a direct flight from Des Moines to Chicago?
Yes, American Airlines and United Airlines operate nonstop flights from Des Moines (DSM) to Chicago (ORD).
Which airlines fly direct from Des Moines to Chicago?
American Airlines, United Airlines operate nonstop flights from Des Moines to Chicago.
How long is the flight from Des Moines to Chicago?
The nonstop flight from Des Moines to Chicago takes ~0h 36m (approximately 480 km).
How much is a round-trip flight from Des Moines to Chicago?
Round-trip flights from Des Moines (DSM) to Chicago (ORD) start at $247, with a typical fare around $301. Based on 343 recent fare combinations.