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Yes. Turkish Airlines and Uzbekistan Airways fly nonstop from Samarkand (SKD) to Istanbul (IST), daily. The flight takes about 4h 37m and covers 1,997 miles (3,214 km).
Turkish Airlines, Uzbekistan Airways operate nonstop flights from Samarkand to Istanbul.
The nonstop flight from Samarkand to Istanbul takes ~4h 37m (approximately 3214 km).
Nonstop flights from Samarkand to Istanbul operate daily.