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Yes. China Eastern Airlines, China Southern Airlines, Juneyao Airlines, Shanghai Airlines and Spring Airlines fly nonstop from Shanghai (SHA) to Guiyang (KWE), several times daily. The flight takes about 2h 26m and covers 935 miles (1,505 km).
China Eastern Airlines, China Southern Airlines, Juneyao Airlines, Shanghai Airlines, Spring Airlines operate nonstop flights from Shanghai to Guiyang.
The nonstop flight from Shanghai to Guiyang takes ~2h 26m (approximately 1505 km).
Nonstop flights from Shanghai to Guiyang operate several times daily.