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Yes. Alaska Airlines and United Airlines fly nonstop from San Francisco (SFO) to Kailua-Kona (KOA), several times daily. The flight takes about 5h 23m and covers 2,366 miles (3,808 km).
Alaska Airlines, United Airlines operate nonstop flights from San Francisco to Kailua-Kona.
The nonstop flight from San Francisco to Kailua-Kona takes ~5h 23m (approximately 3808 km).
Nonstop flights from San Francisco to Kailua-Kona operate several times daily.