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Yes. Alaska Airlines and Southwest Airlines fly nonstop from San Diego (SAN) to Santa Rosa (STS), several times daily. The flight takes about 1h 33m and covers 509 miles (819 km).
Alaska Airlines, Southwest Airlines operate nonstop flights from San Diego to Santa Rosa.
The nonstop flight from San Diego to Santa Rosa takes ~1h 33m (approximately 819 km).
Nonstop flights from San Diego to Santa Rosa operate several times daily.