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Yes. Avianca and Copa Airlines fly nonstop from San Salvador (SAL) to Panama City (PTY), several times daily. The flight takes about 1h 59m and covers 721 miles (1,161 km).
Avianca, Copa Airlines operate nonstop flights from San Salvador to Panama City.
The nonstop flight from San Salvador to Panama City takes ~1h 59m (approximately 1161 km).
Nonstop flights from San Salvador to Panama City operate several times daily.