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Yes. Avianca and Copa Airlines fly nonstop from Panama City (PTY) to San Salvador (SAL), daily. The flight takes about 1h 59m and covers 721 miles (1,161 km).
Avianca, Copa Airlines operate nonstop flights from Panama City to San Salvador.
The nonstop flight from Panama City to San Salvador takes ~1h 59m (approximately 1161 km).
Nonstop flights from Panama City to San Salvador operate daily.