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Yes. Germania, Mann Yadanarpon Airlines, Myanmar Airways International and Myanmar National Airlines fly nonstop from Yangon (RGN) to Mandalay (MDL), daily. The flight takes about 1h 11m and covers 331 miles (533 km).
Germania, Mann Yadanarpon Airlines, Myanmar Airways International, Myanmar National Airlines operate nonstop flights from Yangon to Mandalay.
The nonstop flight from Yangon to Mandalay takes ~1h 11m (approximately 533 km).
Nonstop flights from Yangon to Mandalay operate daily.