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Yes. China Southern Airlines and Spring Airlines fly nonstop from Penang (PEN) to Guangzhou (CAN). The flight takes about 3h 38m and covers 1,522 miles (2,449 km).
China Southern Airlines, Spring Airlines operate nonstop flights from Penang to Guangzhou.
The nonstop flight from Penang to Guangzhou takes ~3h 38m (approximately 2449 km).