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Yes. Cebu Pacific Air, PAL Express and Airphil Express, Philippine Airlines and Philippines AirAsia fly nonstop from Manila (MNL) to Zamboanga (ZAM), several times daily. The flight takes about 1h 35m and covers 529 miles (851 km).
Cebu Pacific Air, PAL Express and Airphil Express, Philippine Airlines, Philippines AirAsia operate nonstop flights from Manila to Zamboanga.
The nonstop flight from Manila to Zamboanga takes ~1h 35m (approximately 851 km).
Nonstop flights from Manila to Zamboanga operate several times daily.