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Yes. Cebu Pacific Air, PAL Express and Airphil Express and Philippine Airlines fly nonstop from Manila (MNL) to General Santos (GES), several times daily. The flight takes about 1h 50m and covers 646 miles (1,040 km).
Cebu Pacific Air, PAL Express and Airphil Express, Philippine Airlines operate nonstop flights from Manila to General Santos.
The nonstop flight from Manila to General Santos takes ~1h 50m (approximately 1040 km).
Nonstop flights from Manila to General Santos operate several times daily.