Direct flights from Chicago to Des Moines MDW → DSM
Southwest Airlines operates nonstop flights from Chicago (MDW) to Des Moines (DSM). The nonstop flight takes around ~0h 37m, covering 305 miles (491 km). Updated 11 June 2026.
MDW
→
DSM
Round trip
1 adult
Economy
Pick dates
Southwest Airlines
WN
Departure Schedule next 7 days
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Frequently asked questions
Is there a direct flight from Chicago to Des Moines?
Yes, Southwest Airlines operates nonstop flights from Chicago (MDW) to Des Moines (DSM).
Which airlines fly direct from Chicago to Des Moines?
Southwest Airlines operates nonstop flights from Chicago to Des Moines.
How long is the flight from Chicago to Des Moines?
The nonstop flight from Chicago to Des Moines takes ~0h 37m (approximately 491 km).