Direct flights from Des Moines to Chicago DSM → MDW

Southwest Airlines operates nonstop flights from Des Moines (DSM) to Chicago (MDW). The nonstop flight takes around ~0h 37m, covering 305 miles (491 km). Updated 11 June 2026.

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More nonstops from Des Moines

DSM → DEN Denver 3 airlines DSM → LAS Las Vegas 2 airlines DSM → LGA New York 2 airlines DSM → ORD Chicago 2 airlines DSM → PHL Philadelphia 2 airlines DSM → PHX Phoenix 2 airlines DSM → SLC Salt Lake City 2 airlines DSM → ATL Atlanta

Frequently asked questions

Is there a direct flight from Des Moines to Chicago?

Yes, Southwest Airlines operates nonstop flights from Des Moines (DSM) to Chicago (MDW).

Which airlines fly direct from Des Moines to Chicago?

Southwest Airlines operates nonstop flights from Des Moines to Chicago.

How long is the flight from Des Moines to Chicago?

The nonstop flight from Des Moines to Chicago takes ~0h 37m (approximately 491 km).

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