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Yes. Iberia flies nonstop from Madrid (MAD) to Santorini Island (JTR), 1–2 times a week. The flight takes about 3h 47m and covers 1,590 miles (2,559 km).
Iberia operates nonstop flights from Madrid to Santorini Island.
The nonstop flight from Madrid to Santorini Island takes ~3h 47m (approximately 2559 km).
Nonstop flights from Madrid to Santorini Island operate 1–2 times a week.