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Yes. American Airlines and Delta Air Lines fly nonstop from New York (LGA) to Indianapolis (IND), several times daily. The flight takes about 1h 52m and covers 659 miles (1,060 km).
American Airlines, Delta Air Lines operate nonstop flights from New York to Indianapolis.
The nonstop flight from New York to Indianapolis takes ~1h 52m (approximately 1060 km).
Nonstop flights from New York to Indianapolis operate several times daily.