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Yes. Avianca and JetBlue Airways fly nonstop from New York (JFK) to Guatemala City (GUA), 5–6 times a week. The flight takes about 4h 45m and covers 2,064 miles (3,321 km).
Avianca, JetBlue Airways operate nonstop flights from New York to Guatemala City.
The nonstop flight from New York to Guatemala City takes ~4h 45m (approximately 3321 km).
Nonstop flights from New York to Guatemala City operate 5–6 times a week.