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Yes. VivaAerobus and Volaris fly nonstop from Cancún (CUN) to Puebla (PBC), several times daily. The flight takes about 2h 4m and covers 757 miles (1,218 km).
VivaAerobus, Volaris operate nonstop flights from Cancún to Puebla.
The nonstop flight from Cancún to Puebla takes ~2h 4m (approximately 1218 km).
Nonstop flights from Cancún to Puebla operate several times daily.