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Yes. China Southern Airlines and Spring Airlines fly nonstop from Chiang Mai (CNX) to Guangzhou (CAN). The flight takes about 2h 31m and covers 977 miles (1,573 km).
China Southern Airlines, Spring Airlines operate nonstop flights from Chiang Mai to Guangzhou.
The nonstop flight from Chiang Mai to Guangzhou takes ~2h 31m (approximately 1573 km).