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Yes. China Southern Airlines, Spring Airlines, VietJetAir and Vietnam Airlines fly nonstop from Guangzhou (CAN) to Ho Chi Minh City (SGN), several times daily. The flight takes about 2h 30m and covers 973 miles (1,566 km).
China Southern Airlines, Spring Airlines, VietJetAir, Vietnam Airlines operate nonstop flights from Guangzhou to Ho Chi Minh City.
The nonstop flight from Guangzhou to Ho Chi Minh City takes ~2h 30m (approximately 1566 km).
Nonstop flights from Guangzhou to Ho Chi Minh City operate several times daily.