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Yes. Iran Airtour and Turkish Airlines fly nonstop from Shiraz (SYZ) to Istanbul (IST), 1–2 times a week. The flight takes about 3h 43m and covers 1,562 miles (2,513 km).
Iran Airtour, Turkish Airlines operate nonstop flights from Shiraz to Istanbul.
The nonstop flight from Shiraz to Istanbul takes ~3h 43m (approximately 2513 km).
Nonstop flights from Shiraz to Istanbul operate 1–2 times a week.