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Yes. Alaska Airlines and United Airlines fly nonstop from San Francisco (SFO) to Palm Springs (PSP), several times daily. The flight takes about 1h 22m and covers 421 miles (677 km).
Alaska Airlines, United Airlines operate nonstop flights from San Francisco to Palm Springs.
The nonstop flight from San Francisco to Palm Springs takes ~1h 22m (approximately 677 km).
Nonstop flights from San Francisco to Palm Springs operate several times daily.