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Yes. Alaska Airlines flies nonstop from San Diego (SAN) to San Luis Obispo (SBP), daily. The flight takes about 1h 3m and covers 263 miles (423 km).
Alaska Airlines operates nonstop flights from San Diego to San Luis Obispo.
The nonstop flight from San Diego to San Luis Obispo takes ~1h 3m (approximately 423 km).
Nonstop flights from San Diego to San Luis Obispo operate daily.