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Yes. Alaska Airlines flies nonstop from San Diego (SAN) to Fort Lauderdale (FLL), daily. The flight takes about 5h 10m and covers 2,264 miles (3,644 km).
Alaska Airlines operates nonstop flights from San Diego to Fort Lauderdale.
The nonstop flight from San Diego to Fort Lauderdale takes ~5h 10m (approximately 3644 km).
Nonstop flights from San Diego to Fort Lauderdale operate daily.