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Yes. Iberia and LATAM fly nonstop from Madrid (MAD) to Santiago (SCL), several times daily. The flight takes about 14h 15m and covers 6,660 miles (10,719 km).
Iberia, LATAM operate nonstop flights from Madrid to Santiago.
The nonstop flight from Madrid to Santiago takes ~14h 15m (approximately 10719 km).
Nonstop flights from Madrid to Santiago operate several times daily.