Is there a direct flight from New York to Knoxville/Maryville?

Yes, American Airlines and Delta Air Lines operate nonstop flights from New York (LGA) to Knoxville/Maryville (TYS).

Which airlines fly direct from New York to Knoxville/Maryville?

American Airlines, Delta Air Lines operate nonstop flights from New York to Knoxville/Maryville.

The nonstop flight from New York to Knoxville/Maryville takes ~1h 18m (approximately 1041 km).

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✈ ~1h 18m 1,041 km LGA on-time 66.6% TYS on-time 67.6%

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American Airlines AA

Delta Air Lines DL