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Yes. ANA, China Southern Airlines and JAL fly nonstop from Tokyo (HND) to Guangzhou (CAN), several times daily. The flight takes about 4h 12m and covers 1,793 miles (2,885 km).
ANA, China Southern Airlines, JAL operate nonstop flights from Tokyo to Guangzhou.
The nonstop flight from Tokyo to Guangzhou takes ~4h 12m (approximately 2885 km).
Nonstop flights from Tokyo to Guangzhou operate several times daily.